Antisense Oligonucleotide Drugs

Functional characterization of alternatively spliced human SECISBP2 transcript variants

Molecular Evolution / Neurochemistry / Immunohistochemistry / Biological Sciences / Phylogeny / Cell line / Environmental Sciences / Humans / Kidney / Ultraviolet / Animals / Muscles / Alternative splicing / Nucleic Acids / Serotonin Receptors / RNA-binding proteins / Insertion sequence / Antisense Oligonucleotide Drugs / Amino Acid Profile / Transfection / Alternative Splicing / Protein isoforms / Amino Acid Sequence / In Silico / Protein Binding / Neurosciences / Full Length Movies / Protein Biosynthesis / Gene Expression Regulation / Mitochondrial Proteins / Molecular Sequence Data / Cell Membrane / Cell line / Environmental Sciences / Humans / Kidney / Ultraviolet / Animals / Muscles / Alternative splicing / Nucleic Acids / Serotonin Receptors / RNA-binding proteins / Insertion sequence / Antisense Oligonucleotide Drugs / Amino Acid Profile / Transfection / Alternative Splicing / Protein isoforms / Amino Acid Sequence / In Silico / Protein Binding / Neurosciences / Full Length Movies / Protein Biosynthesis / Gene Expression Regulation / Mitochondrial Proteins / Molecular Sequence Data / Cell Membrane

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Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

Multidisciplinary / Humans / Caudate Nucleus / Escherichia coli / Female / Animals / Drug Design / Rat Brain / Rats / Antisense Oligonucleotide Drugs / Mechanism of action / Base Sequence / Putamen / Animals / Drug Design / Rat Brain / Rats / Antisense Oligonucleotide Drugs / Mechanism of action / Base Sequence / Putamen

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Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

Multidisciplinary / Humans / Caudate Nucleus / Escherichia coli / Female / Animals / Drug Design / Rat Brain / Rats / Antisense Oligonucleotide Drugs / Mechanism of action / Base Sequence / Putamen / Animals / Drug Design / Rat Brain / Rats / Antisense Oligonucleotide Drugs / Mechanism of action / Base Sequence / Putamen

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Antisense ‘knockdowns’ of M1 receptors induces transient anterograde amnesia in mice

Psychology / Neuropharmacology / Memory / Hippocampus / Cerebral Cortex / Mice / Animals / Amnesia / Male / Reaction Time / Time Factors / Degeneration / Antisense Oligonucleotide Drugs / Neurosciences / Control Group / Mice / Animals / Amnesia / Male / Reaction Time / Time Factors / Degeneration / Antisense Oligonucleotide Drugs / Neurosciences / Control Group

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Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme

DNA replication / DNA damage / DNA repair / Cell line / Humans / Mutation / Animals / Phenotype / Enzyme / Functional integration / Specific Activity / Oxidative Damage / Antisense Oligonucleotide Drugs / Base Sequence / Oxidation-Reduction / Biochemistry and cell biology / Mutation / Animals / Phenotype / Enzyme / Functional integration / Specific Activity / Oxidative Damage / Antisense Oligonucleotide Drugs / Base Sequence / Oxidation-Reduction / Biochemistry and cell biology

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Antisense oligonucleotide inhibition of acetylcholinesterase gene expression induces progenitor cell expansion and suppresses hematopoietic apoptosis ex vivo

Kinetics / Macrophages / Stem Cell / Transcription Factors / Apoptosis / Gene expression / Multidisciplinary / Hematopoietic Stem Cells / Erythropoietin / Cell Differentiation / Mice / Animals / Acetylcholinesterase / Bone marrow / Antisense Oligonucleotide Drugs / Cell Proliferation / Base Sequence / DNA binding proteins / Bone Marrow Cells / Interleukin / Enzyme Induction / Gene expression / Multidisciplinary / Hematopoietic Stem Cells / Erythropoietin / Cell Differentiation / Mice / Animals / Acetylcholinesterase / Bone marrow / Antisense Oligonucleotide Drugs / Cell Proliferation / Base Sequence / DNA binding proteins / Bone Marrow Cells / Interleukin / Enzyme Induction

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Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase

Gastroenterology / Membrane Proteins / Cell Division / Humans / Gastric Cancer / Phosphorylation / Mitogen Activated Protein Kinase / Clinical Sciences / Isoenzymes / DNA binding / Western blot / Antisense Oligonucleotide Drugs / Protein Kinase / Pyrazoles / Neurosciences / Prostaglandin E2 / Cell Growth / Phosphorylation / Mitogen Activated Protein Kinase / Clinical Sciences / Isoenzymes / DNA binding / Western blot / Antisense Oligonucleotide Drugs / Protein Kinase / Pyrazoles / Neurosciences / Prostaglandin E2 / Cell Growth

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A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo

Flow Cytometry / Multidisciplinary / Gene Silencing / Metabolic syndrome / Cell line / Humans / Mice / Animals / Cell Death / Polymerase Chain Reaction / PLoS one / LDL-cholesterol / Cardiovascular Risk Factor / Alanine Aminotransferase / Antisense Oligonucleotide Drugs / Familial Hypercholesterolemia / Cell Survival / Low Density Lipoprotein (LDL) / Intracellular Space / Oligonucleotides / Humans / Mice / Animals / Cell Death / Polymerase Chain Reaction / PLoS one / LDL-cholesterol / Cardiovascular Risk Factor / Alanine Aminotransferase / Antisense Oligonucleotide Drugs / Familial Hypercholesterolemia / Cell Survival / Low Density Lipoprotein (LDL) / Intracellular Space / Oligonucleotides

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Sequence-specific artificial ribonucleases. I. Bis-imidazole-containing oligonucleotide conjugates prepared using precursor-based strategy

Biological Sciences / Environmental Sciences / Nucleic acid hybridization / Molecular Modelling / Nucleic Acids / Substrate Specificity / Antisense Oligonucleotide Drugs / Conformational Analysis / Imidazoles / Base Sequence / Optimality Condition / Ribonucleases / Substrate Specificity / Antisense Oligonucleotide Drugs / Conformational Analysis / Imidazoles / Base Sequence / Optimality Condition / Ribonucleases

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An Electrochemical Probe of DNA Stacking in an Antisense Oligonucleotide Containing a C3′-endo-Locked Sugar

DNA / Nucleic acid hybridization / Electron Transport / CHEMICAL SCIENCES / Antisense Oligonucleotide Drugs / CARBOHYDRATES / Base Sequence / CARBOHYDRATES / Base Sequence

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A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo

Flow Cytometry / Multidisciplinary / Gene Silencing / Metabolic syndrome / Cell line / Humans / Mice / Animals / Cell Death / Polymerase Chain Reaction / PLoS one / LDL-cholesterol / Cardiovascular Risk Factor / Alanine Aminotransferase / Antisense Oligonucleotide Drugs / Familial Hypercholesterolemia / Cell Survival / Low Density Lipoprotein (LDL) / Intracellular Space / Oligonucleotides / Humans / Mice / Animals / Cell Death / Polymerase Chain Reaction / PLoS one / LDL-cholesterol / Cardiovascular Risk Factor / Alanine Aminotransferase / Antisense Oligonucleotide Drugs / Familial Hypercholesterolemia / Cell Survival / Low Density Lipoprotein (LDL) / Intracellular Space / Oligonucleotides

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Antisense ‘knockdowns’ of M1 receptors induces transient anterograde amnesia in mice

Psychology / Neuropharmacology / Memory / Hippocampus / Cerebral Cortex / Mice / Animals / Amnesia / Male / Reaction Time / Time Factors / Degeneration / Antisense Oligonucleotide Drugs / Neurosciences / Control Group / Mice / Animals / Amnesia / Male / Reaction Time / Time Factors / Degeneration / Antisense Oligonucleotide Drugs / Neurosciences / Control Group

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A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo

Flow Cytometry / Multidisciplinary / Gene Silencing / Metabolic syndrome / Cell line / Humans / Mice / Animals / Cell Death / Polymerase Chain Reaction / PLoS one / LDL-cholesterol / Cardiovascular Risk Factor / Alanine Aminotransferase / Antisense Oligonucleotide Drugs / Familial Hypercholesterolemia / Cell Survival / Low Density Lipoprotein (LDL) / Intracellular Space / Oligonucleotides / Humans / Mice / Animals / Cell Death / Polymerase Chain Reaction / PLoS one / LDL-cholesterol / Cardiovascular Risk Factor / Alanine Aminotransferase / Antisense Oligonucleotide Drugs / Familial Hypercholesterolemia / Cell Survival / Low Density Lipoprotein (LDL) / Intracellular Space / Oligonucleotides

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PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

Obesity / Multidisciplinary / Adipose tissue / Blood Glucose / Insulin / Liver / Diabetes mellitus / Mice / Animals / Insulin signaling / Protein tyrosine phosphatase / Enzyme / Protein kinase B / Skeletal Muscle / Antisense Oligonucleotide Drugs / Protein Expression / Base Sequence / Glucose Tolerance Test / Type 2 Diabetes Mellitus / Reference Values / Protein Tyrosine Phosphatases / Insulin Receptor Substrate / Liver / Diabetes mellitus / Mice / Animals / Insulin signaling / Protein tyrosine phosphatase / Enzyme / Protein kinase B / Skeletal Muscle / Antisense Oligonucleotide Drugs / Protein Expression / Base Sequence / Glucose Tolerance Test / Type 2 Diabetes Mellitus / Reference Values / Protein Tyrosine Phosphatases / Insulin Receptor Substrate

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Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells

Clinical Trial / Kinetics / Flow Cytometry / Macrophages / Comparative Study / Gene expression / Multidisciplinary / HIV / Cell line / Humans / Human immunodeficiency virus / Antisense Oligonucleotide Drugs / Base Sequence / Lymphocytes / Active Safety / Antiviral Agents / Molecular Sequence Data / Gene expression / Multidisciplinary / HIV / Cell line / Humans / Human immunodeficiency virus / Antisense Oligonucleotide Drugs / Base Sequence / Lymphocytes / Active Safety / Antiviral Agents / Molecular Sequence Data

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Internalization of oligodeoxynucleotide antisense to type-1 plasminogen activator inhibitor mRNA in endothelial cells: A three-dimensional reconstruction by confocal microscopy

Confocal Microscopy / Cell line / Humans / Spatial Distribution / Endothelial cell / Antisense Oligonucleotide Drugs / ENDOTHELIUM / Three dimensional Reconstruction / Plasminogen Activator Inhibitor / Biochemistry and cell biology / Antisense Oligonucleotide Drugs / ENDOTHELIUM / Three dimensional Reconstruction / Plasminogen Activator Inhibitor / Biochemistry and cell biology

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